AB0085 ANTI-MULLERIAN HORMONE IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Background: Anti-Mullerian hormone (AMH) is one of the key parameters for assessing reproductive function and ovarian reserve. The level AMH correlates with residual follicular pool in women age. Objectives: To assess levels SLE female patients child-bearing potential, analyze relationship between disease severity, as well serum different therapeutic regimens. Methods: study group included 12 aged 20-40 years, control - 15 age-matching healthy women. diagnosis was established based on EULAR/ACR classification criteria, 2019. SLEDAI 2K used to evaluate activity, SLICC index – damage. measured using ELISA. reference values ranged within 1.0-10.6 ng / ml. Values <1.0 were interpreted a decreased Results: patients’ mean age 33.5 [29;38] subjects’ 32.0 [26;35] years. Mean duration 11.5 [2.8;18] Acute, subacute chronic 33%, 17%, 50%, respectively. Disease activity according low 25%, moderate high 42% pts. damage baseline evaluation: no medium 16.5%, high-16.5%. 3.5 ng/ml pts, 3.1 group, showing statistical difference. A decrease reserve (AMH less than 1.0 ml) significantly more common pts vs 13% group. No correlation found index, 2K, or clinical course. Detailed analysis showed that all reduced had CP into their regimens; only exclusion this subgroup i.e., normal level-6 preserved documented patient who received cumulative dose 5.6 g. In other higher, i.e.: 7.2 g, 7.8 10.6 18.4 g 1 per each value. Three 0.1 -0.3 39 years old, while 33-39y are 0.77-5.24 Analysis gynecological history indicate episodes menstrual disorders often reported (50% 20% controls, p =0.001), similarly, diseases also 50% (chronic salpyngo-oophoritis, colpitis, endometriosis uterine endometrioma, subserous myoma, cervical dysplasia, erosion), meanwhile 4 pts; there subject condition teratoma ovaries (favorable outcome surgical removal, fertility two births after surgery). Conclusion: Ovarian compared controls. therapy negatively affects function, most likely dose-dependent manner. study, out 5 additionally compromising Further studies needed clarify potential contribution both autoimmune inflammation development loss fertility. Disclosure Interests: None declared